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Francesco Onofrio Manfredini (June 22, 1684 – October 6, 1762) was an Italian Baroque composer, violinist, and church musician. He was born at Pistoia and studied violin with Giuseppe Torelli. He became a professional violinist, holding important posts in Bologna. He was a teacher for his son Vincenzo Manfredini, who also was a composer and music theorist and served to the Russian Imperial Court.